The current Sesame LIMS is an outgrowth of a project designed by John Markley and Eldon Ulrich at UW-Madison Biochemistry Department for the development of a 'Computerized Desk-Top Management System for Biomolecular NMR.' This project, which was supported by NSF/DBI grant 9604906, made use of experimental software (ZOO Tools) developed at UW-Madison Computer Sciences Department by Miron Livny and Yannis Ioannidis and interfaced to a commercial relational database management system (Informix). However, we found that these experimental tools were not robust enough to deliver reliable results in a laboratory environment.

Hence, Zsolt Zolnai spearheaded a de novo software effort, the current Sesame LIMS, based on standard, commercial and open software packages (Java, CORBA, commercial and open source RDBMS-es.) This project has been initially funded by a four-year supplement to NIH/NCRR grant P41 RR02301, which supports the National Magnetic Resonance Facility at Madison, and it enabled NMRFAM to accelerate the development of the NMR portions of Sesame. This supplement also provided funds for a professional review of the tools and their acceptance by users, which was conducted by the LEAD Center of UW-Madison.

Starting in fall of 2001, additional funding for Sesame was obtained through NIH/NIGMS grant P50 GM64598, which supports the Center for Eukaryotic Structural Genomics (CESG). These funds made possible the rapid growth and development of the Sesame LIMS. The grant enabled the Sesame team to increase the size of its staff as needed to meet the demands of an ambitious structural proteomics project. When the grant ended, the Sesame team had to downsize.

In the meantime, several centers, facilities and laboratories have adopted Sesame and have found it to be robust and extensible to a wide variety of laboratory activities.

The metabolomics part of Sesame was funded by NIH grant 1 R21 KD070297-01, 'Isotope-Assisted Differential Metabolomics.'

Currently Sesame is funded by NIH/NIGMS grant 2R01 GM077139 to support the continued development, testing and dissemination of Sesame LIMS.

The Sesame LIMS is, as it always has been, freely available.